Not if you get you trims to +/- 2%, because you will probably need to increase injector scaling to do that. The injector scaling increase (reducing fueling) will be offset by an increase in LT mid from -25 to 0.
LT low and mid trims are added together to calculate WOT (open loop) fueling. Right now it is subtracting 25% from your fuel map in closed loop mid, and in open loop WOT operation. As your trims wander this will mess with your tip-in, mid and WOT tune quite badly.
Are you running closed loop at idle?