I want to run 18x9.5 with +22 up front and +38 on 265/35/18.

Will this work?

 

as long as your tire size is the same no problem.

but you will have to roll your fenders

 

I can't speak to that particular fitment, although I'd be surprised if that fit without rolling your fenders.

However, running different offsets is not a problem at all. In fact, running a slightly wider front track can help increase front end grip and improve (IMO) the balance of the car. My front track is 40mm wider (20mm per side) in the front vs. the rear, and I prefer it that way.

 

I see I know fender rolling is a must I just want to stay functional. It seems like the front fenders can have some more meet than the rears.

While I know the tires must be the same for awd I didn't know if offsets could make anything go wrong.